Endocrine Abstracts

Hereditable forms account for 30–40% of pheochromocytomas (pheo). The role of germ-line mutation of VHL, RET, SDHB, SDHD gene has been largely elucidated. However, genotyping a group of 172 sporadic or familial pheo, we have characterize five unrelated probands with familial pheo without any sequence variants of RET (7 exons), or of the entire coding sequence of VHL, SDHB, SDHC or SDHD.The proband #1 had a bilateral pheo when 32 and a local recurren...

Vitamin D deficiency seems to be more prevalent in patients with primary hyperparathyroidism (PHPT) than in general population. This association has many clinical and therapeutic implications.The aim of this study was to assess the vitamin D status of patients with PHPT and to describe the clinical presentation of the disease when vitamin D deficiency is associated.Methods: We studied in a retrospective manner, the case of seven pa...

Introduction: The multi-receptor targeted somatostatin analogue pasireotide has high affinity for sst5; this receptor may play an important role in glucose metabolism. Two studies in healthy male volunteers evaluated the mechanism and management of hyperglycemia associated with pasireotide.Methods: A randomized, Phase II study assessed insulin secretion and glucose metabolism during 8 days of pasireotide 600 or 900 μg sc bid (n=19 ...

Pregnancy is associated with an increased risk of tumor growth in macroprolactinoma leading to discuss surgery in such cases.Objectives: Impact of pregnancy on prolactin secretion and tumor growth in a cohort of women with macroprolactinoma, including large tumors >20 mm, and medically treated.Methods: Retrospective study of all the women with macroprolactinomas diagnosed in two university hospitals, treated by dopamine agonist...

Introduction: Metformin induced impaired vitamin B12 absorption leading to fall in serum cobalamin levels has been described in literature as early as 1971. Approximately 10% of patients and in some studies 30% of patients on metformin therapy developed metformin related cobalamin deficiency. The risk of cobalamin deficiency is comparatively more among patients with vegetarian diet than in non-vegetarians.Objective: To evaluate the effect of dose and dur...

Forty seven patients suffering from Addison’s disease (AD: 12 males and 35 females, 44.5±12.7 year old) were compared with 63 normal age-, sex- and BMI-matched subjects.The duration of disease ranged from 0.6 to 44 years (10.23±9.07 years). AD had received a cumulative dose of cortisone acetate of 290.5±326.8 g, equivalent to a daily dose of 44.5±15.5 mg, and to 26.34±10.57 mg/m2 of body surface. AD had average va...

Introduction: Patients with craniopharyngeoma often have disturbances of the hypothalamic–pituitary axis and serious comorbidities as obesity. We hypothesized, that the pattern of hormones regulating the nutritional status is worsened in adult patients with craniopharyngioma (CP) compared to adult patients with non-functioning pituitary adenoma (NFPA).Methods: We included 33 patients with CP (m=16, f=17, median age: 48 years (26–7...

The majority of circulating total 25-hydroxi-D-vitamin (t-25OHD) is bound to proteins – 90% to vitamin D binding protein (DBP) belonging to the alfa-2-globulin (a-2gl) fraction and 10% to albumin (ALB). Nowadays the t-25OHD level is the most accepted marker of vitamin D supply in physiological states. Our aim was to investigate the t-25OHD concentration in clinical conditions with low albumin levels.Methods: Seventy-three patients (39 men, 34 women;...

A 21 years old man had growth failure since 11 y.o., micropenis, high-pitched voice, the absence of secondary sex characteristics and male sexual behavior, constant fatigue and weakness. The boy was born in time after 1st normal pregnancy, birth weight 3000 g, length 57 cm, had unilateral cryptorchidism (surgical treatment in 2002). At the age of 21 the height of the patient was 144 cm (SDS - 4.62), BMI 15 kg/m2 (BMI SDS −3.89), Tanner G1P1, bone age 13 y.o. I...

Introduction: The aim of this study was to evaluate effects on glycemic control, body weight and cardiovascular risk factors (BP, lipids and Epworth sleepiness scale) in diabetic patients with morbid obesity treated with exenatide.Material and methods: We studied consecutively 21 T2DM patients, all of them treated with metformin full dosage and insufficient metabolic control referred to our clinic for preoperative control of bariatric surgery. Twelve of ...